Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases.
نویسندگان
چکیده
Autophagy is a cell survival process which is related to breaking down and reusing cytoplasm components. Moreover, autophagy regulates cell death under certain conditions. Apoptosis has the characteristics of chromatin agglutination and the shrinking of nuclear and apoptosis body form. Even if the mechanisms of autophagy and apoptosis have differences, some proteins modulate both autophagy and apoptosis. Crosstalk between them exists. This review highlights recent advances in the interaction of autophagy and apoptosis and its importance in the development of cardiovascular diseases.
منابع مشابه
Crosstalk Between Autophagy and Apoptosis in Heart Disease [2008;103:343–351] Autophagy in Load-Induced Heart Disease [2008;103:1363–1369] Autophagy in Ischemic Heart Disease Autophagy in Atherosclerosis: A Cell Survival and Death Phenomenon With Therapeutic Potential
Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle macromolecules and organelles. It plays a critical role in removing protein aggregates, as well as damaged or excess organelles, to maintain intracellular homeostasis and to keep the cell healthy. In the heart, autophagy occurs at low levels under normal conditions, and defects in this process cause cardiac dysf...
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ورودعنوان ژورنال:
- International journal of molecular sciences
دوره 17 3 شماره
صفحات -
تاریخ انتشار 2016